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In addition to its base of permanent residents, the island enjoys an influx of both visitors and part-time residents throughout the year.

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The dose and dose frequency of prophylaxis is dependent on the goal of treatment, bleeding phenotype, compliance, venous access and economic resources in the health care system and should be tailored individually based on clinical outcome and pharmacokinetics.

For children, the effectiveness of prophylaxis is more dependent on maintaining minimum trough levels than in adults.

Simons Island is both a seaside resort and residential community.

It is the largest of Georgia's renowned Golden Isles (along with Sea Island, Jekyll Island, and privately owned Little St. Visitors are drawn to the Island for its warm climate, beaches, variety of outdoor activities, shops and restaurants, historical sites, and its natural environment.

This paper reviews the current status on recommendations or guidelines for primary prophylaxis based on recent published papers from organizations or group of experts as well as some original key papers.

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